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盐酸多奈哌齐研究进展 被引量:6

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摘要 随着人类寿命的延长,老年痴呆症患者的数量也在快速增加。盐酸多奈哌齐作为治疗老年痴呆的首选药物,其合成工艺得到了极大的改善。本文综述了盐酸多奈哌齐的合成方法,比较各方法的优缺点,寻找一条适合大规模、商业化生产的工艺路线。
出处 《江西化工》 2005年第1期13-14,12,共3页 Jiangxi Chemical Industry
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参考文献6

  • 1代国林,王长春.安理申[J].中国新药杂志,2000,9(4):273-274. 被引量:15
  • 2process and intermediates for production of donepezil and related[P];US6492522.
  • 3process for produclng multiform crystal of donepezil hydrochloride[P]:W00226709.
  • 4Taichi Abe,Toyokazu Haga .Large scale synthesis of N-benzyl-4-formylpiperidine through partiai reduction of esters using aluminum hydride reagents modified With pyrrolidine: Tetrahedrom57(2001)2701-2710.
  • 5傅宏义,刘倩,孙艳.多奈哌齐——阿尔茨海默病治疗新药[J].药物不良反应杂志,2002,4(1):35-37. 被引量:5
  • 6吴畏 傅若秋.第二代胆碱酯酶抑制剂多奈哌齐的药理作用及临床应用[J]..

二级参考文献6

  • 1Robert Berkow,M.O.默克诊疗手册.北京:人民卫生出版社,1992.866
  • 2Evans DA, Funkenstein HH, Albert Ms, et al. Prevalence of Alzheimer' s disease in a community population of older persons. Higher than preriously reported. JAMA, 1989,262 (18):2551
  • 3徐叔云等.现代实用临床药理学.北京:华夏出版社,1997:542.
  • 4Stern RG, Mohs RC, Davidson M, et al. A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration. Am J Psychiatry, 1994,151(3) :390
  • 5Salmon DP, Thal LJ, Butters N, et al. Longitudinal evaluation of dementia of the Alzheimer type: a comparison of 3standardized mental status examinations. Neurology,1990, 40(8): 1225
  • 6Morris JC. The Clinical Dimentia Rating (CDR): current version and scoring rules. Neurology, 1993, 43 ( 11 ):2412.

共引文献17

同被引文献17

  • 1陈萍,杜浩宇,宋愿智,李淑丽.阿尔茨海默病的药物治疗进展[J].医药导报,2005,24(11):1033-1034. 被引量:12
  • 2Ramon Cacabelos Donepezil in Alzheimer's disease: from conventional trials to phamacogenetics[J]. Neuropsychiatr Dis Treatment, 2007, 3(3): 303-333.
  • 3Courtrey C, Farrell D, Gray R, et al. Long term donepezil treatment in 565 patients with Alzheimer's disease[J]. Lancet, 2004, 363(9427): 2105-2115.
  • 4Ogura H, Kosasa T, Arakis S, et al. Phamacological properties of doneezil hydrochloride(Aricept), a drug for Alzheimer's disease [J]. Nihon Yakurigaku Zasshi, 2000, 115(1 ): 45 -51.
  • 5Esmann,Anal Biochem.Process for the preparation of benzyl-piperidylmethyl-indanones:US,5606064[P].1997-04-25.
  • 6Manne satyanarayana Reddy,Sajja Eswaralah,Mathad Vijayacittha Thiooannachar,et al.Process for preparation of donepezil:US,043121[P].2004-06-22.
  • 7Tarur Venkatasubramanian,Radhakrishnan,Naidu Abinash Venkatraman,et al.Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl)methyl piperidine hydrochloride(donepezil HCl):US,0158070[P].2004-08-12.
  • 8马奇.高等有机化学[M].北京:人民教育出版社,1982:236-237.
  • 9Gutman A L,Shkolnilk E,Tishin B.Process and intermediates for production of Donepezil and related compounds[P].US:6492 522,2002-12-10.
  • 10Esmann M.et al,Anal.Biochem.Process for the preparation of benzyl-piperidylmethyl-indanones[P].US:5 606 064,1997-04-25.

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