多发性硬化患者胼胝体的弥散张量纤维束成像定量研究

Quantitative study of corpus callosum in patients with multiple sclerosis using diffusion tensor tractography

目的 利用弥散张量纤维束成像(DTT)定量研究多发性硬化(MS)患者胼胝体分数各向异性(FA)值与正常志愿者之间的差异及与扩展病残状态评分(EDSS)的相关性,以明确该指标在多发性硬化研究中的价值。方法 对36例正常志愿者和64例复发好转型(RR)MS患者进行弥散张量成像检查,重建出胼胝体并计算出该纤维束的FA值,比较MS组与对照组之间是否存在差异,研究该指标与EDSS的相关性。结果 正常志愿者胼胝体FA值无性别差异(P>0.05),平均FA值为0.506±0.020。MS患者胼胝体平均FA值(0.465±0.033)明显低于(P<0.01)对照组(0.506±0.020)。脑型MS胼胝体平均FA值(0.456±0.036)明显低于脊髓型(0.475±0.025)(P<0.05)。MS患者胼胝体FA值与EDSS评分无显著相关性(r=-0.104,P>0.05)。结论 MS患者胼胝体的FA值存在明显异常,但该指标不能反映患者的身体残疾状态。

Objective To investigate whether there are statistical differences of fractional anisotropy between multiple sclerosis (MS) patients and normal volunteers and whether this index correlated with expanded disability status score (EDSS) in MS patients by using diffusion tensor tractography (DTT), and to determine the role of this index in the study of MS. Methods Thirty-six volunteers and 64 patients with remitting-relapsing multiple sclerosis underwent diffusion tensor imaging. Then corpus callosum was reconstructed, and FA values of them were computed. Differences of FA values of corpus callosum between MS patients and normal volunteers were investigated, and correlation of this index with EDSS was also determined. Results There was no sex difference of the mean FA value of corpus callosum (P>0.05), its mean FA value was 0.506 ±0.020. the mean FA value of corpus callosum (0.465±0.033) of MS group was significantly lower than that of normal contrast group. The mean FA value of corpus callosum of cerebral type of MS (0.456±0.036) was significantly lower than that of spinal type (0.475±0.025)(P<0.05). In MS patients, there wasn't correlation of FA of corpus callosum with EDSS (r=-0.104,P>0.05). Conclusion The mean FA value of corpus callosum of MS group was significantly abnormal, but it can not reflect the status of disability in MS patients.