慢性阻塞性肺病患者血液流变学变化及益气活血中药干预作用

Study on the Changes of Blood Rheology and the Interfere Effect of Herbs with Invigorating qi and Promoting Blood Circulation Effect in Patients with Chronic Obstructive Pulmonary Disease

目的观察慢性阻塞性肺病患者血液流变学变化及益气活血中药干预作用。方法取20例健康者和慢性阻塞性肺病患者48例,将其中48例患者随机分为对照组与治疗组,分别予常规治疗和常规加益气活血中药治疗4周,所有受试者治疗前后均进行肺通气功能、血液流变学测定和生活质量调查。结果与健康组比较,慢性阻塞性肺病患者的通气功能、血液流变学以及生活质量评分的指标有显著差异;治疗后对照组与治疗组的血液流变学指标均明显改善(P<0.05),但后者优于前者(P<0.05);肺通气功能各项指标与生活质量评分有类似变化。结论益气活血中药可改善慢性阻塞性肺病患者的血粘度,提高肺通气功能和生活质量。

Objective: To observe the changes of blood rheology and the interfere effect of herbs with invigorating qi and promoting blood circulation effect in patients with chronic obstructive pulmonary disease (COPD). Methods: 20 healthy cases and 48 cases with COPD were randomly divided into treatment group and control group. Cases in the control group were treated by western routine therapy, cases in the treatment group were treated by western routine therapy and herbs with invigorating qi and promoting blood circulation for 4 weeks. Pulmonary ventilation function, blood rheology and life quality of all cases were detected before and after treatment.Results: As compared with the healthy group, the pulmonary ventilation function, blood rheology and life quality in cases with COPD were significant differences. The indexes of blood rheology in the two groups were all improved notably (P< 0.05), but the later was superior to the former (P< 0.05). The indexes of pulmonary ventilation function and the grade of life quality had similar changes. Conclusion: Herbs with invigorating qi and promoting blood circulation can improve the blood viscosity ,enhance pulmonary ventilation function and life quality of patients with COPD.