花椒温经止痛和温中止泻药理研究

Pharmacological Studies on Warming the Channels to Stop pain and Warming the Middle-jiao to Stop Diarrhea of Pericarpium Zathoxyii

本实验发现花椒醚提物和水提液都能对抗乙酸提高小鼠腹腔毛细血管通透性,抑制二甲苯性小鼠耳壳肿胀和角叉菜胶性大鼠足跖肿胀,减少乙酸引起的小鼠扭体反应次数,醚提物还能延长热痛反应潜伏期。醚提物能迅速而存久地对抗蓖麻油引起的小鼠腹泻,但水提液对抗作用短而弱。然而醚提物不对抗番泻叶引起的小鼠腹泻,水提液却具持久的对抗作用。水提液还能抑制小鼠胃肠推进运动。

Both ethereal extract and aqueous extract of Pericarpium Zanthoxyli antagonized the increased vascular permeability induced by acetic acid in mice, the xylene-induced swelling of mouse ear and the edema of hind paw elicited by carrageenin in rats, and decreased acetic acid-induced the writhing frequency in mice. The ethereal extract also extended the latent period of response to hot stimulation in mice. Its aqueous extract inhibited the gastrointestinal propellent movement, and castor oil-and senna-induced diarrheas in mice, and its ethereal extract only inhi-ted castor oil-induced diarrhea. In the discussion, it was suggested that the anti-inflammatory effect may be a common mechanism for warming the middle-jiao to stop diarrhea and warming the channels to stop pain of Pericarpium Zanthoyli.