肝细胞癌患者PT、APTT、FIB、TT指标变化的初步探讨

Exploration on changes of PT,APTT,FIB.and TT in patients with liver cell cancer

目的:研究肝细胞癌患者凝血试验凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)、血浆凝血酶时间(TT)的变化及临床意义。方法:应用Sysmex CA- 5 30型全自动血凝仪(散射比浊法) ,检测各组血浆中PT、APTT、FIB、TT值。结果:肝细胞癌患者 期+ 期组PT、APTT、FIB、TT分别与其它恶性肿瘤患者组、正常对照组间比较有极显著性差异(P<0 .0 1 ) ,肝细胞癌患者 期+ 期组PT、APTT、FIB、TT分别与其它恶性肿瘤患者组、正常对照组间比较无显著性差异(P>0 .0 5 ) ,其它恶性肿瘤患者组与正常对照组间比较无显著性差异(P>0 .0 5 )。结论:肝细胞癌患者血浆凝血试验(PT、APTT、FIB、TT)参数均有变化,可作为肝细胞癌患者病情危重与预后不良的参考指标。

Objective:To explore the changes and significance of PT,APTT,FIB and TT in patients with liver cell cancer.Methods:PT,APTT,FIB and TT were measured by full-automatic blood of types of sysmex CA-530.Results:PT,APTT,FIB and TT in patients with stage Ⅲ and stage Ⅳ liver cell cancer showed the significant difference as compared with those of the other malignant tumor and normal control subjects(P<0.01).However, PT,APTT,FIB and TT in patients with stage Ⅰ and stage Ⅱ liver cell cancer showed no significant difference as compared with those of the other malignant tumor and normal contral subjects(P>0.05).Conclusion:The changes of PT,APTT,FIB and TT in patients with live cell cancer are determined.These indexes can be used to evaluate the severe degree and prognosis of patients with liver cell cancer.