文迪雅或二甲双胍联合胰岛素治疗2型糖尿病的疗效比较

Curative effect comparison of avandia or metformin combined with insulin on type 2 diabetes

目的 对比探讨文迪雅与二甲双胍治疗单纯胰岛素控制血糖欠佳的2型糖尿病的临床疗效。方法 将4 3例使用皮下注射胰岛素控制血糖欠佳的2型糖尿病患者,随机分为2组,一组加服文迪雅,一组加服二甲双胍,观察治疗前后的空腹血糖(FBG)、餐后2h血糖(2hBG)、糖化血红蛋白(HbA1C)、C肽、胰岛素(INS)用量、胆固醇(TC)、三酰甘油(TG)的变化。结果 FBG、2hBG、HbA1C、INS用量、TG均有明显下降,餐后2hC肽明显上升。结论 文迪雅和二甲双胍均能降低血糖和改善INS抵抗,而文迪雅效果更显著、不良反应少。

Objective It is to compare and discuss the clinical curative effect of avandia and metformin on type 2 diabetes patients whose blood sugar controlled dissatisfactory with insulin only. Methods 43 type 2 diabetes patients whose blood sugar controlled dissatisfactory with insulin only were divided into two groups. Group one was added with avandia and group two was added with metformin. The changes of fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h BG), HbA1C, C-peptide (C-P), insulin dose, total cholesterol (TC) and triglyceride (TG) in the two groups before and after treatment were observed. Results FBG, 2 h BG, HbA1C, insulin dose and TG decreased obviously. The 2 h postprandial C-P increased obviously. Conclusion Avandia and metformin both can lower blood sugar and improve insulin resistance, but avandia has better curative effect and smaller untoward reaction.