摘要
用苯肾上腺素及氯化钡引起血管环收缩，并测定五种血管扩张药对这两种激动剂缩血管作用的拮抗作用的比值。结果表明，灯盏花素的作用与三氟拉嗪相似，是以抑制细胞内钙释放为主。在去除血管内皮的实验中发现，灯盏花素的松弛血管平滑肌的作用，与三氟拉嗪、脑益嗪及硝吡啶均相似，即并不依赖血管内皮的完整性，但从量效曲线来看，灯盏花素与前两者（尤其是与三氟拉嗪）相平行。然而，灯盏花素对五羟色胺的缩血管作用无任何拮抗作用，三氟拉嗪在低浓度时未显示拮抗作用，在高浓度时，可使量效曲线明显右移。这些结果说明灯盏花素的作用可能与拮抗钙调素的作用有关，但确切的机理仍有待进一步探讨。
The antagonism of five kinds
of vasodilators against the vasoconstriction induced byphenylephrine and barium chloride was
studied. The results showed that the action ofbreviscapin (Bre) was similar to that of
trifluoperazine (TFP), chiefly inhibiting therelease of intracellular calcium. In the experiment of
eliminating vascular endothelium,it was found that the vasodilating action of Bre was
independent of the integrity ofvascular endothelium, which was similar to that of TFP,
cinnarizine and nifedipine, andthe dose-response curve of Bre was paralled to that to TFP.
However, Bre did notantagonize the vasoconstriction induced by 5-HT, and TFP also elicited no
antagonismin low dosage but markedly shifted the dose-response curve to the right in high
dosage.It is indicated that the mechanism of Bre is probably related to the antagonism
againstcalmodulin .
出处
《中药新药与临床药理》
CAS
CSCD
1994年第2期15-19,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
灯盏花素
药理学
血管
钙调素
主动脉
平滑肌
breviscapin/pharmacology, muscle, smooth, vascular/drug effect,
aortic rings/drug effect
calmodulin/antagonists inhibitors, vasodilator agents
calciumchannel
blockers
