潜熄宁对高血压模型大鼠的降压实验及发病过程的预防作用

Hypotensive and Preventive Effect of Qian Xi Ningon Hypertension Rat Model

潜熄宁对二肾一夹肾血管性高血压大鼠（２Ｋ１Ｃ—ＲＨＲ）模型，在用药３天后血压即明显下降（ｐ＜０．０１），２周后降到最低，停药一周后虽稍有回升，但仍明显低于给药前（ｐ＜０．０１）。而对造模术后１周的２Ｋ１Ｃ—ＲＨＲ模型预防用药１周后血压上升明显抑制（ｐ＜０．０１），连续给药４周，血压维持在１８ｋＰａ左右，且均明显降低模型左室重（ＬＶ）、右室重（ＲＶ）和ＬＶ／ＲＶ、全心室重／体重（ＶＷＢＷ）的比值（ｐ＜０．０１），明显改善模型的消瘦状况（ｐ＜０．０５），与复方降压胶囊无明显差异（ｐ＞０．０５），但明显优于空白组（ｐ＜０．０１）。

he hypertension ral model was established by clamping of bilateral renal arteries,which was appliedfor the study of the effect of Qian Xi Ning.The blood pressure was significantly lowered (p<0.01) after3 days of Oian Xi Ning administration,and attained the lowest level after 2 weeks.After suspension ofthe drug for one week,the blood pressure rose again but was still lower than the level before drugadministration (p<0.01).After the hypertension model was established for one week, preventiveapplication of the drug for one week can inhibit the elevation of blood pressure(P<0.01),and successiveadministration for 4 weeks maintained the spstolic blood pressure at about 18 KPa.Meanwhile the volumeof left ventricle and right ventricle,LV/RV and ventricular weight/body weight ratios were redueed(P<0.01).The emaciated status of the model was miproved (p<0.05). Its effects showed no significantdifference with Hypotensive Capsule Co. (P >0.05) but superior than the blank control group(P<0.01).