茶碱在慢性阻塞性肺病患者血药浓度的动态分析

Dynamic analysis of theophylline serum concentration in patients with chronic obstructive pulmonary diseases

目的监测慢性阻塞性肺病(COPD)治疗中茶碱的合理血药谷浓度。方法用回顾性分析方法,收集本院近11年来的90例COPD病例,给予小剂量氨茶碱0.125g,静脉滴注,1日2次。在治疗中做过5次以上(平均每人12.5次)茶碱血药谷浓度动态监测。结果90例患者的950次血药浓度结果中,有74.3%分布在3～10μg·mL-1;有85.7%症状得到控制,有6.6%病情好转。大部分患者的茶碱血药谷浓度在3～10μg·mL-1波动。结论用茶碱治疗COPD时,推荐血药谷浓度调控在3～10μg·mL-1。

Objective To explore an ideal rang of the serum trough theophylline concentrations for patients with chronic obstructive pulmonary di- sease (COPD), in order to prevent the adverse effects by irrational medication. Methods It is a retrospective analysis of the dynamic blood trough concentration of theophylline in 90 cases with COPD selected from results of blood concentrations in previous 11 years in Beijing Hospital, combined with the clinical effect and adverse effect at that time. Each case had at least five theophylline concentration results .Results In the 90 cases,(74.3% )theophylline concentration results are fallen into 3～10 μg·mL^(-1). In the rang of 3～10 μg·mL^(-1), 85.7% results corresponded to symptoms control, 6.6% improvement of patient' s condition. The dynamic theophy- lline concentrations of patients changed around 3～10 μg·mL^(-1). Conclusion It is suggested that for the COPD patients, the serum theophylline concentrations should be controlled in the rang of 3~10 μg·mL^(-1).