高脂膳食大鼠血脂和脂质过氧化的变化及灵芝多糖的干预作用

Effects of Ganoderma Lucidum polysaccharides on serum Lipids and lipoperoxidation in Erperimental hyper Lipidemic rats

目的观察不同剂量的灵芝多糖对高脂血症大鼠的血脂及抗氧化功能的影响。方法50只大鼠随机分成5组正常组、高血脂组和不同浓度灵芝多糖处理组,除正常组外,其它组的大鼠采用高脂食物喂养1个月后,鼠尾采血测定TC、TG含量,GSH-Px和SOD活性及MDH含量。结果灵芝多糖能明显降低TC、TG和LD的浓度(P<0.01),同时,灵芝多糖能明显提高血液GSH-Px和SOD酶活性(P<0.01),降低血液MDA的浓度(P<0.05)。结论灵芝多糖能调节大鼠高脂血症的脂代谢和增强抗脂质过氧化的作用。

Objective:To investigate the effect of Ganoderma Lucidum polysaccharides on blood lipid and Lipoperoxidation from the experimental hyperlipidemic rats.Methods:50 rats were randomly divided into normal group,Hyperlipidemia control,200mg/kg and 400mg/kg and 800mg/kg ganoderma Lucidum polysaccharides groups,A part from the tats in control group,the rats in other groups were fed with high fat forage for 30 days,The blood of rat-tait was to determine the Levels of TC,TG,GSH-Px,SOD and MDA.Results:Ganoderma Lucidum polysaccharides could signiticantly decrease the contants of TC,TG in the serum of the experimental hyperLipidemic rats (P<0.01),and mean Level of blood MDA in groups of Ganoderma Lacidum polysaccharides was much lower than that in hyper lipidema group,and the GSH-Px and SOD activities of blood in the group of Ganoderma was much higher than that in Hyperlipidema group.Conclusion:Ganoderma has the effects of regulating Lipid metabolism of hyperidemia and of enhancing the antioxidation and reducing the lipid peroxidaition.