期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Tumstatin——一种来源于人胶原Ⅳ的肿瘤抑制因子 被引量：1

Tumstatin as a tumor inhibitor originated from human collagen IV
下载PDF
导出
摘要 肿瘤的生长和转移都依赖于肿瘤组织内新生血管的形成。tumstatin 是继血管抑素(angiostatin)和内皮抑素(endostatin)之后,最新发现的来源于人基底膜胶原Ⅳ的肿瘤血管形成抑制因子。tumstatin来源(Ⅳ)α3链的N端 54 132 肽能抑制血管内皮细胞增殖和诱导内皮细胞凋亡,N端197 215肽能抑制各种肿瘤细胞增殖。tumstatin及相关多肽独特的作用机制和效应使其成为极具潜力的新型抗肿瘤分子。
作者 罗以勤 王梁华 焦炳华
机构地区 第二军医大学基础部生物化学与分子生物学教研室
出处 《国外医学（临床生物化学与检验学分册）》 2005年第3期173-174,178,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 内皮细胞 细胞凋亡 多肽 肿瘤
分类号 R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1Floquet N, Pasco S, Ramont L, et al. The antitumor properties of the alpha3(Ⅳ)-(185-203) peptide from the NC1 domain of type Ⅳ collagen (tumstatin) are conformation-dependent. J Biol Chem, 2004, 279(3): 2091-2100.
  • 2Maeshima Y, Colorado PC, Kalluri R. Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties. J Biol Chem, 2000, 275(31): 23745-23750.
  • 3Petitelerc E, Boutaud A, Prestayko A, et al. New functions for non-collagenous domains of human collagen type Ⅳ. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo. J Biol Chem, 2000, 275(11): 8051-8061.
  • 4Maeshima Y, Colorado PC, Torre A, et al. Distinct antitumor properties of a type Ⅳ collagen domain derived from basement membrane. J Biol Chem, 2000, 275(28): 21340-21348.
  • 5Hamano Y, Zeisberg M, Sugimoto H, et al. Physiological levels of tumstatin, a fragment of collagen Ⅳ alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell, 2003, 3(6): 589-601.
  • 6Kashtan CE. Alport syndrome and thin glomerular basement membrane disease. J Am Soc Nephrol, 1998, 9(9): 1736-1750.
  • 7Maeshima Y, Sudhakar A, Lively JC, et al. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science, 2002, 295(5552): 140-143.
  • 8Stupack DG, Cheresh DA. ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands. Sci STKE, 2002, 2002(119): PE7.
  • 9Maeshima Y, Manfredi M, Reimer C, et al. Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin. J Biol Chem, 2001, 276(18): 15240-15248.
  • 10Pasco S, Han J, Gillery P, et al. A specific sequence of the noncollagenous domain of the alpha3(Ⅳ) chain of type Ⅳ collagen inhibits expression and activation of matrix metalloproteinases by tumor cells. Cancer Res, 2000, 60(2): 467-473.

同被引文献6

  • 1Maeshima Y ,Colorado PC ,Tone A ,et al. Distinct antitumor properties of a type Ⅳ collagen domain derived from basement membrane [ J]. J Biol Chem ,2000,275 (28) :21340-21348.
  • 2Lu X, Humeau L, Slepushkin V, et al. Safe two plasmid production for the first clinical lentivirus vector that achieves >99% transduction in primary cells using a one step protocol [ J].J GeneMed, 2004,6(9) :963-973.
  • 3Kappes JC, Wu X, Wakefield JK. Production of trans lentiviral vector with predictable safety[ J]. Methods Mol Med ,2003,76 ( 13 ) :449- 465.
  • 4Bartosch B, Cosset FL. Strategies for retargeted gene delivery using vectors derived from lentiviruses [ J ]. Curt Gene Ther,2004,4 ( 4 ) : 427-443.
  • 5陈刚,庞琦,徐广明,王成伟,端木建华,王益华.Angiostatin对脑膜瘤凋亡影响的实验研究[J].山东医药,2002,42(3):22-23. 被引量：2
  • 6郑德华 ,石炳毅 ,蔡明 ,Jing Zhao ,Andrew M.L.Lever .慢病毒介导大鼠肾脏基因转染的实验研究[J].山东医药,2004,44(14):3-5. 被引量：2

引证文献1

国外医学（临床生物化学与检验学分册）
2005年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部