摘要
以间三氟甲基苯胺为起始原料,经重氮化、甲醛肟甲酰化、缩合等三步反应,合成了高纯度的间三氟甲基肉桂酸,总产率为32.0%,并用FT-IR,1HNMR进行了表征。结果表明,最佳反应条件为:在缩合反应中,间三氟甲基苯甲醛/丙二酸/吡啶/无水乙醇(摩尔比)为1:1.11:0.17:3.98,回流6h。
Highly purified m-trifluoromethylstyrene was synthesized from m-trifluoromethyl-aniline with the overall yield of 32.0%through three steps,including diazotization,acylation of formaldozime and condensation.The structure of the products was characterized by FT-IR and ~1H NMR.The results showed that the optimal synthetic conditions were obtained as follows:n(m-trifluoromethylbenzaldehyde):n(malonic acid):n(pyridine):n(anhydrous ethanol)=1∶1.11∶0.17∶3.98,refluxing time about 6h for the reaction of condensation.
出处
《有机氟工业》
CAS
2005年第2期5-7,共3页
Organo-Fluorine Industry
基金
湖南省教育厅资助项目(No03C461)
