糖尿病并发症防治药物研究进展

Advances on the treatment of diabetic complications

糖尿病并发症是随糖尿病(diabetes mellitus,DM)病程的延长而导致的眼、肾、神经、血管及心脏等多组织的慢性病变,是糖尿病致死致残的主要原因。防治糖尿病并发症的药物主要有醛糖还原酶抑制剂、蛋白非酶糖基化阻滞剂、生长激素/胰岛素样生长因子阻滞剂、血流改善剂、抗氧剂和必需脂肪酸、神经营养剂、蛋白激酶C抑制剂等。另外笔者还介绍了一些防治糖尿病并发症的中药和治疗对策。

Diabetic complications are leading causes of several chronic diseases, such as blindness, kidney failure, nervous damage, circulation problems or heart diseases, which were due to worsen ing diabetes mellitus. Some of such complications may lead to disability and death. As the diabetes mellitus becomes better understood, therapeutic options and drugs to prevent or treat diabetes complications have been diversified. Advances on the drug development against the diabetes complications, including aldose reductase inhibitors, nonenzymatic-glucosylation blockers, growth factor/insulin growth factor antagonists, blood effecters, antioxidants and essential amino acids, neurotrophins and protein kinase C inhibitors, are increasingly impressed. This article illustrated current images regarding the research and development of anti-diabetic complications. The therapeutic strategies and the Chinese Traditional Medicines against the diabetic complications were also presented.