幽门螺杆菌感染与胃黏膜相关淋巴组织的相关性探讨

The Relation between Helicobacter Pylori Infection and Gastric Mucosa-associated Lymphoid Tissue

目的探讨幽门螺杆菌(Hp)感染与胃黏膜相关淋巴组织的相关性。方法对经胃镜诊断的慢性浅表性胃炎(CSG)、慢性萎缩性胃炎(CAG)和消化性溃疡(PU)共52例患者的活检胃黏膜进行Warthin-Starry银染色和快速尿素酶试验,以确定有无Hp感染;用HE染色观察淋巴滤泡形成。结果在Hp感染患者(36例)中,有淋巴滤泡者占36.1%(13/36),而无Hp感染的患者均无淋巴滤泡形成。Hp感染阳性者其淋巴细胞浸润、淋巴滤泡形成及慢性活动性胃炎的发生率与Hp阴性者相比差别均有显著性意义(P<0.05)。结论Hp感染与黏膜相关淋巴组织(MALT)淋巴瘤的发生有关。

Objective To find the relation between helicobacter pylori infection and gastric mucosa-associated lympho tissue.Methods Fifty-two patients with chronic superficial gastritis,atrophic gastritis and peptic ulcer underwent gastritis,atrophic gastritis and peptic ulcer underwent gastroscopy and biopsy in the gastric antrum and body.Hp was identified by histopathological analysis (Warthin-Starry silver stains) and rapid urease test (RUT).Lymphoid tissue was observed by HE method.Results Hp infection was found in 6923% of the patients.Lymphoid follicles were present in 3611% of the Hp-positive patients,and no lymphoid was closely associated with gastric mucosallymphoid infiltration,lymphoid follicles and active inflammation (P<0005).Conclusion Hp infection is relative to the occurrence of MALT lymphoma.