复方丹参滴丸对急性冠脉综合征患者CRP及血管内皮功能的影响

Effect of Fufangdanshendiwan on C-reactive Protein and Endothelium-dependent Vasodilatation in Patient with Acute Coronary Syndrome

目的:观察复方丹参滴丸对急性冠脉综合征(CAS)患者C反应蛋白(CRP)及血管内皮功能的影响。方法:93例CAS患者随机分成治疗组47例,对照组46例。各组均以硝酸甘油、长效消心痛片、肠溶阿司匹林片、速避凝针、有溶栓指征者以尿激酶;治疗组在上述治疗的基础上,以复方丹参滴丸两组均于治疗前后1个月,用酶法测定甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)浓度,测定血清C反应蛋白(CRP)、一氧化氮(NO)、内皮素(ET),检测两种治疗方法对患者肱动脉血管内皮依赖性舒张功能(FMD)的影响。结果:治疗前两组各参数无明显著异(P>0.05)。治疗1个月后与治疗前相比,治疗组和对照组的CRP、ET水平均明显下降,NO水平升高(P<0.05或P<0.01),且治疗后两组比较有显著差异(P>0.05);治疗组的TG、TC、HDL-C、LDL-C均下降,FMD升高(P<0.05),而对照组无明显变化(P>0.05),两组比较有显著差异(P<0.05)。结论:复方丹参滴丸可以抑制炎症反应,稳定粥样斑块,改善血管内皮功能,减少CAS的发生。

Objective:To investigate the effect of Fufangdanshendiwan on C-reactive protein(CRP) and endothelium-dependent vasodilatation in patient with acute coronary syndrome(ACS).Method:93 cases ACS patients randomly divided into 2 groups with 47 in the cure group and 46 in the control group:the cure group were treated with Fufangdanshendiwan,10 pill three times a day,orally taken,in addition to routine therapy of ACS and the control group were treated with routine therapy of ACS alone.The changes of plasma triglyeeride(TG),total cholesterol(TC),high density liproteins cholesterol(HDL-C),low density liproteins cholesterol(LDL-C),C-reactive protein,endothelia(ET),nitric oxide(NO)and endothelium-dependent vasodilatation were measured in both groups before and after the treatment.Result:the blood levels of CRP,ET obviously decreased and the level of NO increased in both groups compared with that before treatment( P <0.05 or P <0.01)and the difference between the two groups was significant( P <0.05);the blood level of TG,TC,HDL-C,LDL-C decreased and endothelium-dependent vasodilatation increased significantly in the cure group( P <0.05).But there were no significant differences in control group ( P> 0.05).Conclusion:Fufangdanshendiwan can relieve inflammatory reaction,stabilize atherosclerotic plaque,improve endothelium-dependent vasodilatation and reduce the occurrence of ACS.