高位硬膜外吗啡加氟哌啶乳癌根治术后镇痛观察

CLINICAL STUDY OF UPPER EPIDURAL MORPHINE PULS DROPERIDOLANALGESIA IN POSTOPERATIVE RADICAL MASTECTOMY OF BREAST CANCER

本文对９０例乳癌根治术病人高位硬膜外腔注射吗啡加氟哌啶（Ａ组，ｎ＝３０），吗啡（Ｂ组，ｎ＝３０），０．９％生理盐水（Ｃ组对照，ｎ＝３０），术后镇痛以随机双盲法对比观察。结果：Ａ、Ｂ组镇痛有效率平均达８８．３％，持续时间平均达２８．９６ｈ，与Ｃ组比较有显著差异（Ｐ＜０．０５）；对血气的影响三组间无统计学差异；Ａ组在克服副作用方面优于Ｂ组。作者认为乳癌根治术范围广，创面大，对乳癌根治手术采用高位硬膜外术后镇痛能减轻病人的痛苦及全身性应激反应，而对呼吸的影响较轻，对预防心脑血管意外有一定的作用；高位硬膜外术后镇痛是一种具有临床应用价值的镇痛方法。

Abstract ASA I-Ⅱ patinets who underwent radical Mastectomy of breast cancer were randomlydivided into three groups. Bi-blindly, upper epidural administration of Morphine 2 Mg plus droperidol 2. 5mg (group A,n=30) Morphine 2Mg (group B, n=3),0. 9% N. S (group C, contrast,n=30) were used in postoperative pain relief, separtely. To assess the effect and druation and toobserve the complication of analgesia; Patients were inquired constantly after injection.MAP* P,PH, Pco2,PO2 were measured before and after 18 hours in operation.The results showed the rateof effective. Analgesia was achieved in 88. 3% of the patients in group A and B,The duration ofanalgesia in patients of group A and B were significantly longer than those of group C (P<0.05),complete analgesia can be obtained for average 28.96 hours with no interference with autonomic ormotor function, The Value of Blood gas were similar in three group of patients. The complicationof group A was less than those of others, So that, authors suggested that the patients who will bein careful observation; Upper epidural administration of Morphine-droperidol was an excellentanalgesia method.