不同滋养细胞在恶性滋养细胞肿瘤中的分布

A STUDY ON DISTRIBUTION OF DIFFERENT TYPE OF TROPLHOBLAST IN MALIGNANT TROPHOBLASTIC NEOPLASMS

应用免疫组化方法，采用抗细胞角蛋白（ＣＫ）、绒毛膜促性腺激素（ｈＣＧ）、胎盘泌乳素（ｈＰＬ）抗体，检测了９１例恶性滋养细胞肿瘤不同类型滋养细胞的分布情况。结果显示，侵袭性葡萄胎和绒毛膜癌的滋养细胞组成不同。二者除了均具有较多合体滋养细胞（ＳＴ）外，前者中间型滋养细胞（ＩＴ）数量较后者明显增多，而后者细胞滋养细胞（ＣＴ）则较前者明显增多。转移性侵袭性葡萄胎与原发瘤在滋养细胞组成上无显著差异，但转移性绒毛膜癌ＳＴ较原发瘤明显增多，ＣＴ较原发瘤显著减少，ＩＴ数量虽有一定增加，但与原发瘤无显著差异。作者认为，合体滋养细胞在恶性滋养细胞肿瘤中的作用尚须进一步探讨。

The distribution of different type of trophoblast in 91 malignant trophoblastic neoplasms was studied immunohistochemically using a panel of antibodies against cytokeratin(CK),hCG and hPL.The results showed that the trophoblastic component was different between invasive mole and chorio carcinoma. Although there was numerous syncytiotrophoblast (ST)in both, but the number of intermediate trophoblast (IT) in invasive mole was much more than one in choriocarcinoma, the number of cytorophoblast (CT) in the latter was far more than one in the former. For invasive mole,the discrepancy at cellular component metastatic and primary was not obvious. But for choricocarcinoma, the uumber of ST in metastatic far more than on in primary,the number of CT in the formerwas much less than one in the latter, the number of IT in both did not exhibit evident difference. Webelieved that the role of ST in malignant trophoblastic neoplasms could merit further research.