摘要
本文报道１６１例消化道癌症患者尿多胺的含量分析结果，尿多胺含量比正常人明显增高，比正常均值增高的倍数各为：腐胺０．８６～２．２８倍，精脒０．１１～０．７２倍，精胺２．７６～５．１７倍。本组患者一项多胺增高者占总例数的８８．０％～１００．０％，两项多胺增高者占总例数的６０．８７％～８０．００％。另外，在滤纸电泳图谱的腐胺和精脒色带之间又发现一分离清晰的新色带，在本组患者尿中亦见增高，为正常均值的１．０２～１．４８倍，增高的出现率为４７．０６％～６０．４２％。曾对２１例经手术和２例经化疗的患者进行复查，其各种尿多胺均于治疗后下降，表明尿多胺含量分析可做为消化道癌症患者辅助诊断和估计疗效的参考。
Abstract The amounts of urinary polyamines of 161 patients with cancer of allmentary canai were determined. The urinary polyamines in these patients were significantly higher than those in normal subjects. The putrescine, spermidine and spermine had respectively increased by 0. 86 to 2. 28 times, 0. 11 to 0.72 times and 2. 76 to 5. 17 times. Of the patients, 88.0% to 100% had arise inone of the three polyamines while 60. 87% to 80. 0% in two. Between the putrescine and spermidine in the electrophoregram a histamine-like substance was detected. Whose value was also high,and 1. 02 to 1.48 times higher than the normal value with a positive elevated rate of 47. 06% to60. 42%. Patients' urinary polyamines were reduced as shown by repeated assay maed in 21 casespostoperatively and 2 cases after chmotherapy. The assay of urinary polyamine can be used as anauxiliary method in the clinical diagnosis and therapeutical evaluation of cancer of alimentarycanal.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1994年第1期11-14,共4页
Cancer Research on Prevention and Treatment
