辅助化疗对提高胃癌根治术后远期疗效的临床研究

Adjuvant chemotherapy can improve the late result of radical operation in patients with gastric cancer

我们将２３５例胃癌根治术病例随机分为两组，根治术后加辅助化疗的综合组（１１２例）和单纯根治术组（１２３例），研究辅助化疗的临床意义，总的５年生存率综合组为５１．８％，明显高于单纯根治术组的３０．９％（ｐ＜０．０１）．其中Ⅱ期胃癌５年生存率综合组与单纯根治术组相比，为７０．７％：４１．３％，差异有非常显著意义（ｐ＜０．０１）；Ⅲ期胃癌为４８．７％：２６．８％，差异亦有显著意义（ｐ＜０．０５）；而Ⅰ、Ⅳ期胃癌两组间差异无显著意义（ｐ＞０．０５）．本研究结果表明，辅助化疗对提高各期胃癌根治术后远期疗效的作用不同，并分析了其原因．

In order to study the clinical significance of adjuvant chemotherapy,We randomly divided 235patients who have received radical operation for gastric cancer into two groups. The combinationgroup consisted of 112 cases who were given adjuvant chemotherapy after the operation,While 123cases in operative group received radical opertion only. The aggregate 5-year survival rate of thecombination group (51. 8%) is significantly higher than that of the operative group (30. 9% )(p<0. 01). Correalting the disease stages with 5-year survival rate,stage Ⅱ with combination therapygives significantly higher survival rate than simple radical operation (70. 7% VS 41. 3% ) (p<0.01). Stage Ⅲ with combination therapy is also significantly different from simple radical operation(48. 7% VS 26. 8%) (p<0. 05). White for stage Ⅰand stage IV no such significant difference wasobserved (p>0. 05). Our results indicate that postoperative adjuvant chemotherapy can to variousdegrees improve late result of radical resection of different stages of gastric cancer.