三苯氧胺联合化疗治疗晚期恶性黑色素瘤──附16例临床分析

Observations and clinic analysis of combined chemotherapy on advanced melanocy-toma with tamoxifen in 16 cases

本文报告了三苯氧胺＋化疗治疗１６例晚期恶性黑色素瘤的临床疗效，目前恶黑的治疗仍以手术切除为主，但术后复发率高；放疗对其相对不敏感；单独化疗对进展期恶黑的有效率＜３０％。ＴＡＭ＋ＤＴＬＣ＋ＣＣＮＵ用于存在有雌激素受体的恶黑患者的治疗，其近期有效率达６２．５％，特别对青年女性患者，效果更为喜人，毒副作用小，简便易行，患者易于接受。

Abstract The effects of combined chemotherapy on advanced melanocy - toma .with tamoxifen in 16cases were reported. Treatment for such diseases consists mainly of surgery, with high recurrence, radiotherapy, in low susceptibility, or pure chemotherapy whose effective rate used to be'less than 30 percent recently i while our work showed a short--term effeCtive rate up to 62. 5 percent with the combined chemotherapy of TAN + DTIC + CCNU in cases of malignant melanocy toma with existence of estrogen retrogen. With aged women patients, the effeCts were even better, being of lower POisonous or side effects and of simplicity. The sufferers would prefer taking this treatment.