摘要
目的合成针对肿瘤血管的新一代高效低毒抗癌物质CA-4,并改进工艺。方法本文以廉价的异香兰素为起始原料,经过Wittig等六步反应合成CA-4。结果所得产物经IR和1HNMR确证。结论原料廉价,工艺易过渡于工业生产。
OBJECTIVE To provide a new process for preparing CA-4 used as an agnet for anti-tumour. METHOD The product was synthesized from inexpensive isovanillin by six-step reactions. RESULT The chemical structure of the product was determined by IR and 1 HNMR. CONCLUSION The method is suitable for industry.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2005年第3期210-211,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
抗肿瘤
合成
anti-tumour
synthesis