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肿瘤血管生成抑制剂CA-4的合成 被引量：6

Synthesis of tumour vascular inhibitor CA-4
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摘要 目的合成针对肿瘤血管的新一代高效低毒抗癌物质CA-4,并改进工艺。方法本文以廉价的异香兰素为起始原料,经过Wittig等六步反应合成CA-4。结果所得产物经IR和1HNMR确证。结论原料廉价,工艺易过渡于工业生产。 OBJECTIVE To provide a new process for preparing CA-4 used as an agnet for anti-tumour. METHOD The product was synthesized from inexpensive isovanillin by six-step reactions. RESULT The chemical structure of the product was determined by IR and 1 HNMR. CONCLUSION The method is suitable for industry.
作者 杨兆琪 邱国福 粱淑彩 胡先明
机构地区 武汉大学药学院
出处 《中国现代应用药学》 CAS CSCD 北大核心 2005年第3期210-211,共2页 Chinese Journal of Modern Applied Pharmacy
关键词 抗肿瘤 合成 anti-tumour synthesis
分类号 TQ460.6 [化学工程—制药化工]
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参考文献10

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中国现代应用药学
2005年 第3期

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