利用SPSS估算血管外给药的药动学参数

Estimating the pharmacokinetic parameters in extravascular administration by SPSS

目的利用SPSS估算血管外给药室模型的药动学参数。方法使用SPSS的非线性回归(nonlinearregression)拟合模拟的两室模型血管外给药的药时数据;依据95%置信区间决定是否在模型中保留滞后时间(tlag)项。结果SPSS估算的药动学参数准确可靠;根据tlag95%置信区间决定是否在模型中保留tlag项是合理的。结论SPSS适用于估算血管外给药室模型的药动学参数。

OBJECTIVE To estimate the pharmacokinetic parameters of compartment models with extravascular administration using SPSS.METHOD Concentration-time data from the simulation of two-compartment model with the 1st order absorption and lag time( t _ lag ) were fitted using SPSS nonlinear regression. 95% confidence interval (95% CI) for t _ lag was used to determine if t _ lag item remained in the model.RESULTS The pharmacokinetic parameters obtained from SPSS were exact and reliable. It was reasonable to determine if t _ lag item remains in the model according to its 95% CI.CONCLUSION SPSS is suitable for estimating the pharmacokinetic parameters of compartment models with extravascular administration.