肉鸡腹水综合征发病机理研究进展

Research Advance Ascites Sydrome On the Mechanism of Broiley

快速生长等病因使机体氧不足,产生OFR,导致血管内皮细胞损伤.首先,内皮细胞损伤引起以非肌性动脉肌性化,肌性动脉中膜平滑肌增厚,外膜下胶原纤维增多为特征的肺血管重构.肺血管重构时,血管壁增厚,内径缩小、僵硬,弹性回缩力缩小而形成PS.其次,内皮细胞损伤使有缩血管作用的TXA2和EDCF合成增加,而有舒血管作用的PGI2和EDRF合成减少,肺血管收缩加强,再加上血栓的阻力,形成PS.高Na+通过使胃肠内容物渗透压升高,液体从血液中向胃肠腔渗漏,血液PCV值升高;ED下降,血流阻力增大;血容量增加三方面导致PS.PS出现早于右心肥大.PS引起右心肥大和AS.PS使右心负荷增大,久之右心衰竭,静脉回流受阻,肝脏淤血.肝毛细血管压力升高,大量滤出液进入肝淋巴管而使其压力上升,淋巴液从肝被膜和肝淋巴管渗出而形成腹水.PS是AS发病机理的中心环节.AHI(RV/TV)是学术界公认的研究AS的参数,它反映了心扩张程度和肺动脉压的高低,可以做为AS的诊断根据.大量的试验数据表明:右心室越重,右心区面积越大,腹水越多.AS病鸡的AHI值>0.40.

<Abstrcat>A lot of pathogencics,such as guick growth,made the oxygen of the body insufficient and produce OFR,caused the internal cell of blood vessel lesion.First,the internal cell lesion made the blood vessel of the lung reform,its feature was that non-muscular arteries made muscularize.The smooth muscle of tunica media in the muscular arteries thicken,the collagenous fiber of the tunica externa increase.At the same time,the blood vessel wall thicken,its inside diameter shorten and stiff,its elasticity reduce,so that PS was formed.Second,becuse the internal cell lesion made TXA_2 and EDCF increase that their use was to contract the blood vessel,instead,PGI_2 and EDRF reduced that their use was to expand the blood vessel,so its contractility was strengthened in the blood vessel of lung,and plus the resistance of the internal clot,so PS was formed.High consistency Na^+ made the permeation of stomach and intestines rising,the liguid in the blood permeated into the stomach and intestines,the number of PCV in the blood was going up;the number of ED was coming down and the blood flow resistance and the blood volume were increasing,because of this three respects PS was formed.PS made the right-side heart fat,and increased its burden,as time passes,the right-side heart failure,the return flow of the vein was stopped and this liver was extravastaed blood.Because the pressure of capillary in the liver rises,a lot of filtrate get into the lymphatic vessel of the liver,and made its pressure rising,the lymph oozed out of the adventitia and the lymphatic vessel of the liver,so the ascites syndrome was formed.PS was the key link of the pathogenesis of AS.AHI(RV/TV) was a reference number of AS and this is known to the academic circles,because it showed the heart expansibility and the arterical tension of the lung,so it can be made the diagnostis base for AS.A large number of test data showed:the right ventricose heart was more heavier and the right-side heart area was more bigger,so the ascites was too much.The number of AHI of the chicken AS was bigger than 0.40.