138例妊娠滋养细胞疾病住院病例临床分析

Clinical analysis of 138 hospitalized cases of gestational trophoblastic disease

目的:了解妊娠滋养细胞疾病病例的临床特征。方法:回顾性分析住院病例临床资料。结果:共调查138例,平均年龄28岁,农村病例占63.04%;80.74%的病例有阴道不规则流血;侵蚀性葡萄胎、绒癌的转移率分别为13.56%和44.23%;侵蚀性葡萄胎病例都有葡萄胎病史,间隔半年以内发病者占80.00%;绒癌的先行妊娠以葡萄胎为主,占47.73%,其中间隔1年以上发病者占57.14%。结论:妊娠滋养细胞疾病以农村病例居多,阴道不规则流血为最主要的特征性表现,绒癌转移率高于侵蚀性葡萄胎。先行妊娠的种类及间隔时间在临床鉴别诊断中具有一定的参考价值。

Objective: To investigate the clinical characteristics of the hospitalized cases of gestational trophoblastic disease, and supply valuable information for the clinical practice and the pathogenesis studying.Methods:Analysis of historic normol material by epidemiology descriptive study, look back the clinical information of the gestational trophoblastic disease's patients who had been in the No. 1 and No. 2 affiliated hospital of Chonging university of medical science from 1992 to 2002.Results:There were 138 cases, including 26 for hydatidiform mole,60 for invasive mole, and 52 for choriocarcinoma. The average age was 28-year-old, the minimum was 18- year-old, the maximum was 50-year-old. 63.04% of the cases were from countryside. 97.64% had the history of induced abortion. 80.74% of cases had symptom of the unregulated vagina blooding.All invasive mole cases had the histories of hydatidiform mole,among whom 80.00% happened within half a year.47.73% choriocarcinoma cases had the histories of hydatidiform mole,among whom 57.14% happened over one year.Conclusion:The majority of cases are countrywomen. According to the main clinical symptom, the unregulated blooding of vagina is its characteristic. The choriocarcinoma's transfer rate is higher than that of the invasive mole. The category and interval of previous gestation have an importance referential value in differentiating and diagnosing gestational trophoblastic disease.