肝积方配合氩氦刀联合TACE治疗中晚期原发性肝癌48例疗效观察

Treatment of Intermidiate and Advanced Stage of Primary Liver Cancer by Ganji Fang Associated with Argon - Helium Knife and Hepatic Artery Chemotherapy Embolization: A Clinical Observation of 48 Cases

目的:观察肝积方配合氩氦刀联合肝动脉化疗栓塞(TACE)治疗中晚期原发性肝癌的疗效。方法:将105例患者随机分为3组。肝积方组(A组)32例,以肝积方(处方:柴胡、白芍、党参、白术、茯苓、莪术、水蛭、白花蛇舌草、土鳖虫、半枝莲、生牡蛎、甘草)治疗;肝积方加氩氦刀联合TACE组(B组)48例,以肝积方加氩氦刀联合TACE治疗;氩氦刀联合TACE组(C组)25例,以氩氦刀联合TACE治疗。主要观察近期疗效、远期疗效及治疗前后机体活化T细胞指标CD3+/HLA-DR+、血瘀状态指标CD62P、卡氏评分、生存质量(QOL)评分。结果:3组近期疗效比较,差异均无显著性意义(P>0.05)。治疗后除卡氏评分外,CD3+/HLA-DR+、CD62P、QOL评分等治疗前后差值B组与A、C组比较,差异均有非常显著性意义(P<0.01);卡氏评分治疗前后差值A、B组升高,C组明显下降,C组与A、B组比较,差异均有显著性意义(P<0.05)。结论:肝积方配合氩氦刀联合TACE治疗中晚期原发性肝癌可提高机体免疫力,显著改善血瘀状态,其预后佳,并可提高远期疗效。