摘要
目的研究不同剂量的双环醇片治疗慢性乙型肝炎(cHB)的疗效和安全性。方法随机选择139例 CHB 患者分2组接受治疗,口服双环醇片150mg/d(治疗组)或75mg/d(对照组),观察连续用药24周后的疗效和安全性。结果 2组血清氨基转移酶均得到明显下降,且治疗组更为明显(P<0.05);治疗24周后治疗组与对照组 HBeAg 阴转率分别为36.1%和20.9%(P<0.05),均未发生明显的不良反应。结论双环醇片150mg/d 治疗 CHB 在降低血清氨基转移酶及 HBeAg 阴转方面优于75mg/d,安全性好。
Objective To analyze the efficacy of bicyclol in treatment of chronic viral hepatitis B(CHB)at different doses and de- termine its safety.Methods A total of 139 patients with CHB were divided into two groups and received bicyclol orally 150rag daily or 75mg daily for 24 weeks.The efficacy and safety were observed.Results Compared with pre-treatment,the serum aminotransferase was decreased obviously in two groups,and 150 mg daily group was better(P<0.05 ).HBeAg negative conversion rate of bicyclol 150 mg daily group and 75 mg daily group was 36.1% and 20.9%,respectively(P<0.05).There were no obvious adverse events which were probably related to bicyclol in the study.Conclusions In terms of decreasing aminotransferace(ALT/AST)level and HBeAg negative conversion,Bicyclol 150 mg daily is more effective than 75 mg daily.
出处
《传染病信息》
2005年第2期80-81,共2页
Infectious Disease Information
