细胞核病理特征对甲状腺乳头状癌的诊断价值

THE VOLUE OF THE NUCLEAR PATHOLOGICAL FEATURES IN THE DIAGNOSIS OF PAPILLARY THYROID CARCINOMA

对１４０例甲状腺乳头状癌（ＰＴＣ）的一组与诊断有关的病理性核特征的光镜细胞学和电镜超微结构观察显示：ＰＴＣ中透明核出现率８７．１％、沟核９７．１％、核内包涵体８０．０％、核重叠８１．４％、核分裂象２４．２％。除核分裂象以外，其余四种核特征阳性率明显高于各对照组，差异均具有非常显著性（Ｎ０．０１），而且阳性病征数量较多、分布范围较广。结果提示，除核分裂象外，其余几种病理性核特征对ＰＴＣ的诊断、鉴别诊断有重要参考价值。本文还结合电镜观察结果对各种光镜下核病理特征的形成机理作了探讨。

group of nuclear pathological features of papillary thyrold carcinoma(PTC)were examed in 1 40 casesby LM and EM. Among these,87.1%were found positive for the clear nuclei,97.1%for the grooved nuclei.80.0%for the intranuclear inclusions,81.4%for the nuclear overlap,and 24.2%for the nuclear mitosis. Sta-tistically,very significant differences were found between PTCand individual controlling groups in all feattiresmentioned above(p<0.01).The results suggest that the nuclear pathological features excetp the nuclear mi-toses have practlcal value in the diagnosis of PTC. How the nticlear pathological feagures are formed was dis-cussed based on the rerults of the electromicroscopic examination.