人胎肝细胞条件培养液对大鼠中毒性肝坏死的实验研究

The study of the effects of conditional cul-ture solution of human fetal liver cells on ex-perimental toxic hepatic necrosis

为了研究肝细胞生长因子的来源,本文对人胎肝细胞条件培养液促肝细胞增生活性进行了研究。用D#氨基半乳糖造成大鼠肝坏死模型后,观察人胎肝细胞条件培养液的治疗效果。结果表明,此条件培养液能显著地促进肝细胞增生,改善实验性肝坏死的病理变化,并能提高实验动物的存活率。

For investigating the sourse of hepatocyte grouth factor, the proliferating activity of cultured solu-tion of conditional medium of human fetal liver cells (hFLC) was observed. Hepatic necrosis modelswere induced by D- Gal in wister rats. The results showed that the conditional culture solution of hFLCmay prominantly improve the pothohogical changes of experimental necrosis, promote the regenerationof liver cells, and raise the survival rates of experimental animals.