白血病患者血管内皮生长因子血浆水平的评价

CLINICAL SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PLASMA OF PATIENTS WITH ACUTE LEUKEMIA AND CHRONIC LEUKEMIA

目的探讨急性、慢性白血病患者血管内皮生长因子(VEGF)血浆水平与白血病之间关系。方法应用酶联免疫吸附法(ELISA)定量检测32例急性、慢性白血病患者和20例对照组血浆VEGF含量。结果白血病患者化疗前、后血浆VEGF含量均明显高于对照组(P<0.01)。结论急性、慢性白血病存在肿瘤性血管新生。

Objective To evaluate the role of the plasma vascular endothelial growth factor(VEGF) levels in patients with acute leukemia and chronic leukemia. Methods The VEGF levels in the plasma were measured by sandwich ELISA in 32 leukemia patients and 20 control group. Results The plasma VEGF levels in leukemia patients before and after treatment were significantly higher than those in control group (P<0.01). Conclusion There was tumour angiogenesis in acute and chronic leukemia.