病毒性肝炎患者血清脯氨酸肽酶活性测定及其意义分析

DETECTION AND ANALYSIS OF SERUM PROLIDASE ACTIVITY IN VIRAL HEPATITIS

本文对100例各型病毒性肝炎患者的血清脯氨酸肽酶(PLD)活性进行了检测。并与血清ALT,PCⅢ,白蛋白及胆红素进行了比较。结果发现,除慢迁肝外,其他各型肝炎的PLD活性均明显高于正常对照(p<0.01)。其中以急性肝炎最高,慢活肝次之。经直线相关分析显示PLD活性变化与ALT活性有非常显著的相关性(p<0.01)。二者的异常率均在80％以上。重症肝炎的PLD活性虽有增加,但在幅度与异常率方面均低于前二者。在慢性肝炎中,尚发现PLD活性与PCⅢ的活性高低有关(p<0.01)。而与白蛋白无关。此外,PLD活性也显示与胆红素的高低有关。从而提示PLD活性是反映肝细胞坏死与纤维化的有用指标。

(Abstract)The serum prolidase(PLD)activity in 100 cases of various types of viral hepatitis was determined.and comparedwith serum ALT、PC Ⅲ、albumin and bilirubin. The results showed that in all types of viral hepatitis except CPH,the concentra-tion of PLD was significantly elevated above the controls(p<0.01). Acute hepatitis showed the most prominent.and CAH thesecond. Linear correlation analysis showed that the changes in PLD activity was in very significant corretation with that of ALT(p<0.01). 80% of both showed abnormal PLD values. Though the PLD activity in fulminant hepatitis was increased .but theamplitude and abnormality rate were lower than the first two. In chronic hepatitis,the PLD activity was correlated with that ofserum PC Ⅲ(p<0. 01)and bilirubin .but not serum albumin. These results suggested that PLD activity is an indicator of bothhepatic necrosis and hepatic fibrosis.