MRI测量颞叶钩回间距对老年期痴呆的诊断价值

Value of the Interuncal Distance Measured from MRI in the Diagnosis of Dementia

对１０例Ａｌｚｈｅｉｍｅｒ氏病（ＡＤ）、２０例血管性痴呆（ＶＤ）、８例混合性痴呆（ＭＤ）以及９０例同年龄组健康老人的ＭＲＩ颞叶钩回间距进行了比较研究，结果显示ＡＤ组与ＶＤ组、ＡＤ组与同年龄健康老人组有显著性差异。作者认为，迄今为止，常规ＭＲＩ仍不失为诊断老年期痴呆的可靠方法。以评估颞叶钩回间距为主的ＭＲＩ图像综合性分析，有助于鉴别ＡＤ、生理性脑老化、ＶＤ及ＭＤ，具有一定的临床价值。这种方法与ＭＲＩ诊断原则的应用，将为老年痴呆的防治研究提供一条新的诊断途径。

Purpose: To assess the value of the IUD measured from MR in evaluating the demented patients.Methods: MRI measurements of the IUD were made and compared in 10 patients with Alzheimer's disease(AD), 20 patients with vascular dementia (VD), 8 patients with mixed type dementia and 230 healthy control subjects. Radiologic-pathologic correlation was reviewed in one patient with MD. Results: The mean IUD for AD group was 34.5mm and the mean for control group was 24.6. There was a singnificant difference of the IUD between AD and control groups. The mean IUD for MD group was 27.5mm and the mean for VD group was 24.9mm,A difference of the IUD was shown between MD and VD groups. Both coronal MR scan and corresponding gross autopsy specimen in a patient with MD showed disproportional atrophy of the temporal lobes. The IUD was 40mm. Conclusions: The results suggest that the IUD measured from MRI may provide an accurate and sensitive differential diagnosis between AD and other types of dementia.