抗凝药物对血小板形态影响的电镜观察

Electron Microscopic Observation on Morphology of Platelets Effected by Anticoagulating Agents

利用H-300透射电镜观察43例冠心病患者血小板形态及24例用抗凝药物治疗后的血小板形态改变,同时观察血液流变学及甲皱微循环变化。结果表明:冠心病患者聚集型血小板明显增多,树突型血小板突起多而长。血粘度增高,甲皱微循环异常。用潘生丁、阿斯匹林、低分子右旋醣酐等药物治疗后,聚集型血小板减少,聚集堆以不同方式离散或出现解聚倾向,树突型血小板突起变少变短。血粘度降至正常范围。甲皱徵循环改善。几种药物中以阿斯匹林效果最佳。

Morphology of platelets in 43 cases of the patients with coronary heart disease (CHD)and 24 cases of the patients treated with anticoagulating agents was observed by transmiting electron microscope, meanwhile the hemorheology and the hyponychial mi-crocirculation of the patients were monitored. The results showed that: Of the CHD patients, the platelets of aggregating type were increased significantly,the processes of dendritic type platelets were more and long,the hemoviscosity was high,hyponychial micro-circulation was abnormal. After the patients were treated with persantin,aspirin and dextran 40,the platelets of aggregating type were decreased and the platelets aggregating piles dispersed by different ways or presented a disaggregating trend,the processes of dendritic type platelets were less and short. The hemoviscosity lowered to normal range,the hyponychial microcirculation became better than that of pretreated with anticoagulation agents. Of the studied agents,aspirin showed the best effect.