^(123)I-间碘苄胍显像对儿童神经母细胞瘤诊断和分期的临床价值

^(123)I-MIBG Imaging in Neuroblastoma of Children:Evaluation in Diagnosis and Clinical Classification

分析了１０９例初诊的神经母细胞瘤（ＮＢ）和节神经母细胞瘤（ＧＮＢ）患儿及５９例其它肿瘤患者的^（１２３）Ｉ－间磺苄呱（ＭＩＢＧ）显像结果，^（１２３）Ｉ－ＭＩＢＧ检出神经母细胞瘤的准确率是９２％，与其它影像学方法（ＣＴ、超声、Ｘ线）以及骨髓组织细胞学检查方法相比较，^（１２３）Ｉ－ＭＩＢＧ的灵敏度对原发瘤是９０％，对骨或骨髓转移是８３％，对于尿中儿茶酚胺含量正常的患者检出病灶的灵敏度是８０％，本研究证明^（１２３）Ｉ－ＭＩＢＧ作为一种高灵敏度，高特异性的示踪剂在神经母细胞瘤的诊断及分期中起着重要的作用。

patients with neuroblastoma(NB)and ganglioneuroblastoma(GNB)and 59 patients with other tumors were studied with￣(123)I-MIBG before oncologic treatment.Accuracy for detection of NB was 92%.For primary tumor,results of MIBG scans were compared with morphological examinations,For bone marrow metastases,it was compared with extensive cyto-histological examinations of 10 bone marrow sites,Sensitivity for primary tumor and for bone marrow metastases were 90% and 83%,respectively.For patients with normal excrection of urinary catecholamine,sensitivity was 80% for detection of NB lesions.This study showed that the sensitive and specific￣(123)I-MIBG scintigraphy played an important role in the diagnosis and classification of NB.