X-连锁凋亡蛋白通路调控及在脑缺血中的表达
摘要
X连锁凋亡蛋白(XIAP)是凋亡抑制蛋白家族(IAPs)中抗凋亡作用最强的成员,通过抑制始动或效应半胱天冬酶(Caspases)活性发挥抗凋亡作用。但受到第二个线粒体源性Caspase激活剂/低等电点的IAP直接结合蛋白(Smac/DIA-BLO)、XIAP相关因子1(XAF1)和需求高温的丝胺酸蛋白酶A2(HtrA2)等相关因子的负性调控。脑缺血后XIAP通路基因表达增高,参与了脑缺血后细胞凋亡的动态发展。
出处
《国外医学(神经病学.神经外科学分册)》
2005年第3期273-276,共4页
Foreign Medical Sciences(Section On Neurology & Neurosurgery)
基金
广西科技厅自然科学基金(桂科自0135006)
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