Caveolin-1在膀胱癌的表达及其与膀胱癌生物学性状关系

The Relationship between Caveolin-1 Expression and the Biological Character of Bladder Carcinoma

目的探讨caveolin1在膀胱癌中的表达及其与膀胱移行细胞癌(以下简称为膀胱癌)生物学性状的关系。方法采用SABC免疫组织化学法分析63例膀胱癌组织及15例正常膀胱粘膜中caveolin1表达,结合临床病理资料采用χ2检验进行统计学分析。结果正常膀胱粘膜中caveolin1无表达,膀胱癌组织中caveolin1阳性表达率为34.92%。其中G1、G2、G3期膀胱癌阳性率分别为0%、2.86%、54.28%,病理分级间比较有显著性差异(P<0.01);临床分期Ta～T4阳性率分别为0%、25%、52.94%、40%、50%,各期间比较有显著性差异(P<0.01)。结论caveolin1在膀胱癌的高表达与其病理分级及临床分期有密切的关系,对膀胱癌生物学性状评估有重要意义。

Objective To explore the expression of caveolin-1 in bladder carcinoma and the relationship between Caveolin-1 and biological character of bladder carcinoma. Methods Expression of caveolin-1 in urothelial carcinoma of the urinary bladder was determined in 63 cases of bladder carcinoma tissues and fifteen normal mucous membrane of urinary bladder cases with SABC immunohistochemical method, and clinic pathological data of patients were collected and used to make statistical analysis. Results The positive rate of caveolin-1 expression was 34.92% in 63 cases of bladder carcinoma tissues, but no expression of caveolin-1 found in the mucosa of normal urinary bladder. The percentages of the positive cases for Cav-1 were 0%, 2.86%, 54.28% in pathological grades from grade one to grade three respectively(P<0.01). The percentages of the positive cases for Cav-1 in clinic stages of Ta, T1~T4 were 0%, 25%, 52.94%, 40% and 50% respectively (P<0.001) . Conclusion High expression of caveolin-1 in bladder carcinoma was positively related to the pathological grade and the clinic stage of tumor, which might be a valuable maker for the biological character of bladder carcinoma.