摘要
肝脏再生是一个极其复杂、多因素参与的过程,而其中的细胞因子起着至关重要的作用。这些因子主要包括:起始因子或者前炎性因子如肿瘤坏死因子(TNFα)、白细胞介素6(IL6)等;肝细胞生长因子(HGF)等生长因子;辅助肝细胞分裂原如胰岛素和肾上腺素等;转化生长因子β(TGFβ)等持续性肝细胞生长抑制因子;生长抑制因子的抑制因子,如:LAP(TGFβN末端肽段)等。前三类细胞因子分别对处在G0期、G1期、S期的肝细胞起直接或间接作用,而后两类因子对前三种因子起到促进或者抑制的作用。本文旨在探讨肝再生各主要相关细胞因子在肝再生过程中的作用机制以及它们之间的相互关系。
Liver regeneration is a very complicated and many regulation factors involved process, and many kinds of cytokines act very important roles on liver regeneration. These cytokines include priming factors or proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) etc, growth factors like hepatocyte growth factor (HGF) etc, comitogens such as insulin and epinephrine etc, tonic growth inhibitors including activin A and growth factor beta (TGF-β), suppressors of growth inhibitors such as TGF-β inhibitor known as latency associated peptide (LAP) etc. The first three kinds of cytokines respectively affect on the heptocytes in G 0, G 1 and S phase; and the last two cytokines show the stimulatory or inhibitory effects on the first three factors. This review aims to discuss the action mechanisms and correlations of various key cytokines in liver regeneration.
出处
《解剖科学进展》
CAS
2005年第2期174-179,共6页
Progress of Anatomical Sciences
