期刊文献+

Evaluation of HAART by HIV-1 Quantitative Method and Immunological Function Inspection

Evaluation of HAART by HIV-1 Quantitative Method and Immunological Function Inspection
下载PDF
导出
摘要 Objective: To observe the effectiveness of highly active antiret-rovirus therapy (HAART) on HIV/AIDS patients. Methods: Using HIV-1 quantitative methods and immu-nological function inspection, we monitored 4 HIV/AIDS pa-tients who were suffering from immunological deficiency andwere treated with HAART Results: The reproduction of HIV in all 4 patients was effi-ciently controlled at the 4th week of the treatment. The averageviral load decreased by 1.99 Log/ml (0.73-2.46 Log/ml). Thenumber of CD^+_4 and CD^+_8 showed a steady continuous increase4 to 12 weeks after the treatment, with an increase of 67.2%and 103.0% respectively. Correlative study among differentvariables after the treatment revealed that positive correlationexisted between the number of CD^+_4 and CD^+_3 as well as CD^+_8,while negative correlation existed between the number of CD^+_4and plasma viral load. Conclusion: HIV-1 quantitative method (plasma viral load)and the number of CD^+_4 in peripheral blood can be used asimportant reference indicators in evaluating HAART. Objective: To observe the effectiveness of highly active antiretrovirus therapy (HAART) on HIV/AIDS patients. Methods: Using HIV-I quantitative methods and immunological function inspection, we monitored 4 HIV/AIDS patients who were suffering from immunological deficiency and were treated with HAART. Results: The reproduction of HIV in all 4 patients was efficiently controlled at the 4th week of the treatment. The average viral load decreased by 1.99 Log/ml (0.73 - 2.46 Log/ml). The number of CO+4 and CD+s showed a steady continuous increase 4 to 12 weeks after the treatment, with an increase of 67.2% and 103.0% respectively. Correlative study among different variables after the treatment revealed that positive correlation existed between the number of CD+4 and CD+3 as well as CD+8,while negative correlation existed between the number of CD+4 and plasma viral load. Conclusion: HIV-I quantitative method (plasma viral load)and the number of CD+4 in peripheral blood can be used as important reference indicators in evaluating HAART.
出处 《Chinese Journal of Sexually Transmitted Infections》 2001年第1期30-33,共4页 中华性传播感染杂志(英文版)
关键词 HIV/AIDS HAART Viral load Immunological function HAART HIV-1 爱滋病病毒 病毒感染 定量检查 免疫功能
  • 相关文献

参考文献8

  • 1Stanley SK,Ostrowski MA,Justement Js. et al.Effect of immnunization with a common recall antigen on viral expression in patients infected with human, immunodeficiency virus (HIV) type 1[].The New England Journal of Medicine.1996
  • 2Hubert JB,Meyer I,Dussaix E, et al.Prognostic value of early HIV-1 RNA levels on disease progression in 363 Patients with a know date of infection in: program and abstracts of the Ivconf of Retrovirus and opport infant Washington[]..1997
  • 3.Conveys for Disease control: 1993 revised classification system HIV infection and expanded surveillance case definition for AIDS among adolescents and adults[].Morb MortalWkly Rep.1992
  • 4Sulkowski MS,Chaisson RE,Karp CL,et al.The effect of acute infectious illnesses on plasma human immunodeficiency virus (HIV) type 1 load and the expression of serologic markers of immune activa-tion among HIV-infected adults[].Journal of Infectious Diseases The.1998
  • 5Tokars J I,Marcus R,Culver D H,et al.Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood[].Annals of Internal Medicine.1993
  • 6Poli,Kinter A,Justement JS,et al.Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunod-eficiency virus expression[].Proceedings of the National Academy of Sciences of the United States of America.1990
  • 7Fabey J L,Taylor J M,Detels R,et al.The prognostic value of cellular and serologic markers in infection with human imunodeficiency virus(HIV)type I[].New England Journal of Medicine The.1990
  • 8Lange J M A,de wolf F,Goudsmit J.Markers for progression in HIV infection[].AIDS.1989

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部