摘要
Objective : To investigate the role and clinical significance of p16 protein in Condyloma Acuminatum (CA) and its cancerization. Methods: The expression of p16 protein was tested in 33 CA samples and 7 cancerized CA samples by immunohistochemical assays. Results: There was abnormal expression of p16 protein in CA and cancerized CA, mainly major protein expression. The p16 protein expresseed in different locations in different cases was as follows: In basal layer cells in normal cuits; in spinous layer, granular layer and stratum corneum layer cells in CA;in keratin pearl peripheral and spinous layer cells in cancerized CA. Conclusion.. There was major expression of p16 protein in CA and cancerized CA, and these protein of the two groups might not naturally be the same. Our study indicated that in clinical practice, when major p16 protein expression in CA occurs, it's risk of cancerization shoud be suspected.
Objective: To investigate the role and clinical significance ofp16 protein in Condyloma Acuminatum (CA) and itscancerization. Methods: The expression of p16 protein was tested in 33CA samples and 7 cancerized CA samples byimmunohistochemical assays. Results: There was abnormal expression of p16 protein inCA and cancerized CA, mainly major protein expression. Thep16 protein expresseed in different locations in different caseswas as follows: In basal layer cells in normal cuits; in spinouslayer, granular layer and stratum corneum layer cells in CA;in keratin pearl peripheral and spinous layer cells incancerized CA. Conclusion: There was major expression of p16 protein inCA and cancerized CA, and these protein of the two groupsmight not naturally be the same. Our study indicated that inclinical practice, when major p16 protein expression in CAoccurs, it's risk of cancerization shoud be suspected.
