支气管哮喘患儿TNF、IL-8和GM-CSF检测的临床意义

Clinical Significance of Determination of Serum TNF, IL-8 and GM-CSF Levels in Pediatric Patients with Bronchial Asthma

目的:探讨了支气管哮喘患儿血清TNF、IL-8和集落刺激因子(GM-CSF)水平的变化及临床意义。方法:应用放射免疫分析测定了32例支气管哮喘患儿血清中TNF、IL-8和GM-CSF含量,并与30名正常健康儿童作比较。结果:支气管哮喘患儿血清中TNF、IL-8和GM-CSF水平均非常显著地高于正常组(P<0.01)经一周治疗后与正常人组比较仍有显著性差异(P<0.05)。结论:观察支气管哮喘患儿血清中TNF、IL-8和GM-CSF水平的变化,对探讨其发病机理,指导临床用药具有十分重要的临床价值。

Objective To investigate the clinical significance of changes of serum TNF,IL-8 and GM-CSF in pediatric patients with bronchial asthma. Methods Serum TNF,IL-8 and GM-CSF levels were measured with RIA in 32 pediatric patients with bronchial asthma and 30 controls. Results Serum levels of TNF,IL-8 and GM-CSF were very significantly higher in pediatric patients with bronchial asthma than those in controls (P<0.01). After one week treatment, the levels dropped considerably but still remained significantly higher than those in controls (P<0.05). Conclusion These cytokines participated in the pathogenesis of bronchial asthma. Monitoring the changes of their serum levels was helpful for the management of the diseases.