摘要
本文对80例血液恶性肿瘤患者观察了血拴前状态表现。发现急性白血病化疗前临床出血症状明显,除血小板生成受肿瘤细胞干扰外,血管内皮细胞 PGI_2异常释放亦参与形成急性白血病的出血因素,故6—酮—前列腺素(6—酮—PGF_(1a))增高为主。慢性白血病及其它血液恶性肿瘤对血小板、血管内皮细胞及肝功能的作用,导致血拴烷 B_2(TXB_2)、VWF 升高,6—酮—PGF_(1a)、抗凝血酶—Ⅲ(AT—Ⅲ:C)降低,形成肿瘤患者血拴前状态的另一个特点。
We observed the pre-thrombus status of eighty hematopoietic malignancy patients and foud out that the cause of evident hemorrhage for acute leukemia before chemotherapy are; a.The interference on maturation of platelets by tumor cells,b.The abnormal release of PG1 in endothelial cells of blood vessels.Therefore the increase of 6-ketone-PGFla is dominant in such patieut.However,to chrohic leukemia and the other hematopoietic malig- nancies,the main manifestation is the increase of TXB_2 and VWF,and the decrease of 6-ke- tone-PGFla and AT-Ⅲ :c.That is another charateristic of-the pre-thrombus status of hematopoietic malignancy patients.
