摘要
本文报告应用 CHOP 方案(环磷酰胺、阿霉素、长春新碱、泼尼松)治疗53例非何杰金氏淋巴瘤的临床经验。全部患者均经病理组织学证实。按工作方案分类,低度恶性11例,中、高度恶性42例。化疗在3疗程以上,治疗结果,全组总缓解率83.5%,完全缓解率52.8%。40例初治病例总缓解率92.5%,完全缓解率77.5%。主要毒副作用为白细胞降低、脱发和消化道反应,多能耐受。部分病例出现心电图改变,无心力衰竭发生。
53 cases of NHL,all histologically proved,were treated with CHOP regimen chemother- apy.78.9% of the cases were median grade and high grade lymphoma,according to the working formulation.In some cases,adjuvant radiotherapy were also applied to the bulky disease area follwing chemotherapy. Results for the whole group:total response rate was 83.5% and CR rate was 52.8%. For 40 previously untreated cases,total response rate was 92.5% and CR rate was 77.%%. Side effects including leucopenia,alopecia and EKG changes were reversible,and no fatal toxieity was encountered.The data suggested that CHOP regimen is the first line therapy for median and high grade NHL.
