较长时间肠外营养支持病人加用生长激素的临床观察

Effects of recombinant human growth hormone combined with relative longterm parenteral nutrition in G-I patients

目的观察重组人生长激素（rHGH）对较长时间接受肠外营养（PN）支持患者的影响。方法16例患者接受传统肠外营养2周后，加用rHGH（8～12IU／d）2周。观察患者应用rHGH前后尿氮排出量和体重的变化。结果患者在加用rHGH2周后较单纯接受传统肠外营养时体重有所增加（50．2±4.2kgvs52.3±4.3kg，P＝0．01）；尿氮排出量在联合应用rHGH3天后明显减少（P＝0．026）。重要脏器功能未见明显变化。结论提示场外营养支持联合应用rHGH可以增加患者体重，减少尿素氮排出量。

objectvie Growth Hormone (GH) improves anaboism and cell proiferation. The puny of this study was to observe the effect of recombinant human growth hormone (rHGH) combined with long team parenteral nutrition (PN) on nitrogen my. Methods 16 patients were enrolled. Affter receiving soely PN (30 Kcal· kg-·d-) for 2 weeks, patients were treated by rHGH (8~12IU/d) with PN for 2 weeks. Results Showed the weight of patients increased after treatment of PN combined with rHGH,urine nitrogen significiantly decreased after combining rHGH 3 days. Conclusions These data had suggest that treatment of PN combine with rHGH results a increased patienb they weight and decreased urine nitragon.