顽固性癫痫的微循环临床研究

Clinical Study on Microcirculation of Patients with Obstinate Epilepsy

作者对50例顽固性癲痫(EP)患者和30例正常人进行甲襞和球结膜微循环对比观察,结果显示:EP组存在明显微循环障碍,同对照组比较有非常显著差异,P<0.01.。对EP组试用大剂量山莨菪碱后,病情完全缓解者达44%,治疗前后微循环观察差异显著。本研究提示,脑微循环障碍可能是顽固性癲痫的重要发病机理和难治因素之一。

The nailfold and bulbar conjunctival microcirculation were observed on 50 cases with obstinate epilepsy (EP). The results showed that there were markedly disturbance on microcirculation of EP group the comparision between EP group and control group(30 cases of healthly person) that there were very significantly difference (P<0. 01). After treatment of EP group with anisodamine, the patients of 50 cases were alleviated in 40% than before, also, the disturbance of microcirculation were alleviatedl. It suggests which is stasis of brain microcirculation may be a very important machinism for obstinate epilepsy.