摘要
每片含磷酸可待因15 mg,扑热息痛300 mg的复方制剂-氨酚待因2号片(PC-2)的身体依赖性用多种实验模型作了评价。PC-2在小鼠的用药剂量为相应临床日剂量(CDD)的6-20倍产生了身体依赖性,但大鼠的给药剂量为3CDD就产生了依赖性,然而,PC-2或磷酸可待因的日剂量为4CDD却不引起猴产生身体依赖性。这些结果表明PC-2具有一定程度的身体依赖性,PC-2在动物产生的身体依赖性有种属差异。
No. 2 acetaminophen-compound tablet(PC-2) is a mixture medicine tablet made of 15 mg codeine and 300 mg paracetamol. Physical dependence on PC-2 was evaluated in various tests. When the mice received dose of 3-20 times corresponding to clinical daily dose (CDD) of PC-2, physical dependence on PC-2 developed. But depen- dence on PC-2 occurred only 3 CDD of PC -2 in rats. However, no physical dependence on PC-2 was observed in 4 CDD of PC-2 in monkeys. These results suggest that PC-2 enable animals to produce physical dependence, but its potency is relatively low. The de- velopment of physical dependence varies with strain.
