摘要
羟甲芬太尼(OMF)和吗啡分别sc 1.5μg·kg^(-1)和1.0 mg·kg^(-1)后对小鼠的醋酸扭体反应有很好的抑制作用。以上述剂量间隔12 h重复给药,OMF和吗啡对扭体反应的抑制率随给药次数增加而下降;热板镇痛实验sc OMF 3μg·kg^(-1)吗啡15 mg·kg^(-1),其镇痛阳性率仍随给药次数增加而下降。OMF耐受组和吗啡耐受组交叉给药,各组耐受性仍然存在。这些结果表明OMF和吗啡的镇痛效应都有耐受性,且二者存在交叉耐受。小鼠毒性耐受实验显示OMF的毒性反应亦存在耐受性。
The development of tolerance to analgesic effect of ohmefentanyl(OMF) and morphine was studied by writhing test and hot - plate test in mice. Actually single sc of OMF 1. 5 μg . kg^(-1) and morphine 1. 0 mg . kg^(-1) inhibited writhing response. However, analgesic effect of both OMF and morphine at the same dosage remarkably reduced after 4, 8 and 12 times with repeated administration at interval of 12 hours. Hot - plate tests of OMF and morphine showed the same results as that of writhing test. Furthermore, the cross -administration of the two drugs could not improve analgesic effects. All these sup- ported that OMF and morphine could develop tolerance to their analgesic effects, and they also had cross tolerance. In addition, toxicity of OMF in mice demonstrated the tolerance de- veloped to toxicity of this drug.
