喹啉类药物中毒的病理变化—动物实验研究

The Pathological Changes of Quinolines Poisoning: An Experimental Study

喹啉类药物是常用的抗疟药，都是奎宁的衍生物，主要有8-氨基喹啉类和4-氨基哇啉类。近年还用喹啉类药物治疗阿米巴病、肺吸虫病，华支睾吸虫病、类风湿性关节炎、红斑性狼疮、心律失常、硅肺和癌症等，由于治疗的疗程长，总剂量大，

The histological and ultrastructural features of the laboratory animals ncluding dogs, monkeys and rats were observed in the experiments of quinolines poisoning. The morphological alterations in the myocardium and conduction systems were the important pathological changes in the intoxicated dogs. The changes in the liver were mild and reversible.Some ntoxieated rats revealed severe adrenal lesions.