双丁酰cAMP对癌细胞膜上凝集素受体的影响及其与侵袭能力的相关性

The Effect of db cAMP on Lectin Receptors and Invasive Ability of Human Lung Adenocarcinoma Cells

双丁酰ｃＡＭＰ是一种诱导分化剂，对体外培养的癌细胞具有一定诱导分化作用。本文着重观察了双丁酰ｃＡＭＰ对培养的人肺腺癌细胞膜上多种凝集素受体表达的影响，并将体外经双丁酰ｃＡＭＰ处理的癌细胞接种于裸鼠皮下，观察移植瘤自发性生长状况。结果表明，经双丁酰ｃＡＭＰ处理的人肺腺瘤细胞表面数种凝集素受体表达降低，同时伴有移植后成瘤潜伏期延长、侵袭能力下降。由于癌细胞膜结构和功能的改变与癌细胞的识别粘附及侵袭能力密切相关，这一结果提示双丁酰ｃＡＭＰ对癌细胞膜的影响可能是恢复癌细胞间粘附识别作用，降低其侵袭能力的机制之一。

We studied the effect of db cAMP on the expression of several surface lectin receptors in vitro and the invasive ability of AGZY 32 cells in vitro. The results showed that the cells treated with db cAMP manifested the decreased expression of lectin receptors and reduced the invasive ability in nude mice. These results suggest that the effect of db cAMP on the lectin receptors of carcinoma cells may be one of the mechanisms involved in the alternation of cellular invasive phenotype.