儿茶酚胺致心肌损伤的病理实验研究

AN EXPERIMENTAL PATHOLOGICAL STUDY OF MYOCARDIAL DAMAGE INDUCED BY CATECHOLAMINE

大鼠尾静脉滴注去甲肾上腺素后不同时期(即刻、7、30、90、150天)分别处死取材,用病理组织学、肌红蛋白免疫组化染色及透射电镜观察心肌损伤。结果:急性期心肌呈多灶性坏死,肌红蛋白缺染,肌原纤维溶解断裂,类似人冠状动脉无阻塞性心肌梗塞;急性期后心肌继续灶性溶解、萎缩,成纤维细胞增生活跃,新生胶原纤维伸入心肌坏死灶及其周围间隙,使病灶疤痕化及内膜增厚,类似人早期心肌病病理图象。

An experimental study of myocardial damage was induced in Wistar rats following noradrenaline infusion(20 ug/kg body wt/minute),for a period of 90 minutes daily for three consecutive days,the animals were killed after some minutes(acute phase),7 days(subacute phase),30-90 days(chron- ic phase),observed by histopathological,myoglobin immunohisto-chemical and ultrastructural me- thods.The results demonstrated multiple focal necrosis and myoglobin defects of myocytes,my- ofibrillar fragmentation and dissolution in the acute phase,this morphological feature simulated human cases of myocardial infarction without coronary occlusion.After acute phase,focal atrophy and scars of myocardium,active proliferaton of fi- bre(?) asts and neo-collageous fibrils infiltrated in r(?)crofic myocytes are present,this feature si rula- ted the early cardio-myopathy.