恶性胰岛细胞瘤14例诊治分析

Malignant Islet Cell Tumor:14 Cases Report

目的探讨恶性胰岛细胞瘤诊治的经验,以期提高诊断和治疗水平。方法回顾分析1980年1月～2004年4月收治的56例胰岛细胞瘤患者资料,其中恶性胰岛瘤14例,占25.00%。结果本病临床症状不典型,上腹部肿块为其主要症状,术前定位相对容易,定性诊断困难诸多,B超和CT是其主要的检查手段。14例患者均行手术探查,肿瘤摘除术1例,胰体尾切除加脾切除术6例,胰十二指肠切除术5例,肿瘤活检2例。其中1例一期行肝转移灶切除。5年存活率50.00%。结论本病需将病理检查和肿瘤生物学行为结合起来判定良、恶性,手术切除是治疗本病的有效方法,综合治疗有望提高其生存率。

Objective: ?To study the characteristics of malignant islet cell tumor. Methods: ?Data of 14 patients with malignant islet cell tumor in Huaxi Hospital from Jun,1980 to Apr,2004 were analyzed retrospectively. Results: ?The major symptom was abdominal mass.Ultrasound and CT examinations played an important role in detecting this disease.All 14 patients underwent operation:one patient underwent tumor enucleation,5 pancreaticoduodenectomy,6 resection of the spleen and pancreatic body-tail,1 resection of liver metastsis.2 biopsy because of wide infiltration.Overall 5-year survival rate was 50%. Conclusion: ?Both pathological examination and biological behavior of the tumor should be considered to judge whether the tumor is benign or malignant.Surgical resection is an effective treatment method. [