肺癌P53表达与临床病理特征及预后关系的研究

Relationship between expression of P53 in lung cancer and clinical pathological characteristics as well as prognosis

目的探讨大、小细胞肺癌中P53的表达及其在肺癌发生、转移以及预后中的意义。方法采用S-P免疫组化染色技术及显微分光光度术,检测86例肺癌P53的表达情况。结果肺癌P53的表达与肺癌淋巴结转移及临床分期有关,P53的表达与患者的生存率有关,但与组织学分级及分化程度无关。P53阳性率及强度,在肺癌伴淋巴结转移阳性组高于淋巴结转移阴性组(P<0.01)。随着临床分期的增高,阳性率逐渐增高(P<0.05)。P53阳性患者术后3年生存率明显低于阴性者(P<0.05)。结论对肺癌进行P53的检测,有助于预测肺癌进展程度和淋巴结转移的诊断,以及评估肺癌患者的预后。

Objective To investigate the expression of P53 in lung cancer and its clinical significance in the carcinogenesis,metastasis and prognosis of lung cancer.Methods The expressions of P53 in 86 patients with lung cancer were detected by SP immunohistochemistry and microspectrophotometry.Results The expression of P53 was related with the lymph node involvement rate and related with the TNM classification.The positive rate of P53 was higher in positive lymph node group than that in negative lymph node group ( P <0.01).The later the pathologic stage,the lower the positive rate ( P <0.05).The 3-year survival rate in patients with P53-positive was lower than that of patients with P53-negative ( P <0.05).Conclusion The determination of P53 may contribute to assessing tumor progression and lymphatic metastasis and predicting prognosis of patients with lung cancer.